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Akute myeloische Leukämie / Acute myeloid leukemia

3.12.2010

http://www.physorg.com/news/2010-12-clue-leukemia-mystery-poison-deadly.html
New clue in leukemia mystery: Researchers identify 'poison' employed by deadly enzyme mutations
acute myelogenous leukemia (AML), IDH1 IDH2, TET2

29.3.2011

http://blogs.discovermagazine.com/80beats/2011/03/28/discovered-genetic-misfires-that-lead-to-acute-myeloid-leukemia
Discovered: Genetic Misfires That Lead to Acute Myeloid Leukemia
Misfires nucleophosmin AML

3.12.2011

http://www.jhoonline.org/content/2/1/23
Molecular prognostic markers for adult acute myeloid leukemia
normal cytogenic AML (NC-AML), NPM1, FLT3, MLL, and CEBP-alpha, AML-subgroups, Acute Promyelocytic Leukemia (APL, M3 subtype), Nucleophosmin Gene (NPM1), Fms-like tyrosine kinase 3 Gene (FLT3), MLL, CCAT/Enhancer Binding Protein Alpha Gene (CEBP-alpha), Brain and Acute Leukemia Cytoplasmic (BAALC), MN1, ERG, AF1q

31.1.2011

http://www.physorg.com/news/2011-01-southampton-scientists-patient-trials-leukemia.html
Southampton scientists begin patient trials of new leukemia cancer vaccine
DNA-vaccine, BCR-ABL, chronic myeloid leukaemia, AML, tyrosine kinase inhibitors

17.1.2011

http://www.physorg.com/news/2011-01-radical-treatment-leukemia.html
Radical treatment for leukemia under way
hematopoietic-stem-cells, acute myelocytic leukemia, killing leukemia stem cells, immunologically humanized mice, leukemia-stem-cells, stem-cell niche, pathogenesis of leukemia, Fumihiko Ishikawa, Leonard Shultz, Osamu Ohara, Yoriko Saito, cytokine-treatment

5.9.2011

http://medicalxpress.com/news/2011-09-gene-defect-predisposes-people-leukemia.html
Researchers discover gene defect that predisposes people to leukemia
acute myeloid leukemia and myelodysplasia, GATA2 mutations, RUNX1 and CEBPA mutations

11.11.2010

http://www.physorg.com/news/2010-11-key-mutation-acute-myeloid-leukemia.html
Researchers discover key mutation in acute myeloid leukemia
DNA methyltransferase 3A, DNMT3A

3.6.2011

http://medicalxpress.com/news/2011-06-stem-cell-treatment-leukemia-closer.html
Stem cell treatment to prevent leukemia returning is a step closer, say scientists
Bmi1 Hoxa9 MLL AML

3.12.2011

http://www.medindia.net/news/Novel-Targeted-Therapy-Shows-Promise-To-Eliminate-Leukemia-Stem-Cells-54175-1.htm
Novel Targeted Therapy Shows Promise To Eliminate Leukemia Stem Cells
CD123 AML 7G3 antibody

3.12.2011

http://www.eurekalert.org/pub_releases/2010-12/jtcc-jtc120310.php
John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
MLN8237, Investigational Aurora A Kinase (AAK) Inhibitor in Patients with Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndromes (MDS)

5.9.2009

http://news.ucsf.edu/releases/new-research-strategy-for-understanding-drug-resistance-in-leukemia/
New research strategy for understanding drug resistance in leukemia
MEK inhibitor, AML

26.10.2011

http://medicalxpress.com/news/2011-10-compound-common-wart-treatment-leukemia.html
Compound found in common wart treatment shows promise as leukemia therapy
acute myeloid leukemia, anti-leukemic-agent, Peter A. Crooks, AAPS

9.11.2008

http://www.wissenschaft.de/wissenschaft/news/297113.html
Sequenzierung der kompletten DNA einer Krebspatientin entlarvt bösartige Mutationen
Leukämie Gene, akute myeloische Leukämie (AML) , Timothy Ley, weiße Blutkörperchen

17.7.2011

http://derstandard.at/1308680960933/Blutkrebs-Arbeitsgruppe-identifiziert-eine-Art-Schalter-fuer-AML
Arbeitsgruppe identifiziert eine Art Schalter für AML
akute myeloische Leukämie, MEIS1, Michael Heuser

11.7.2011

http://derstandard.at/1308680960933/Blutkrebs-Arbeitsgruppe-identifiziert-eine-Art-Schalter-fuer-AML
Arbeitsgruppe identifiziert eine Art Schalter für AML
Schalter-für-AML, akute myeloische Leukämie, Michael Heuser MEIS1

23.1.2009

http://www.eurekalert.org/pub_releases/2008-12/wsw-dpd121008.php
Data presented demonstrate prolonged overall survival for patients with acute myeloid leukemia
AML, VIDAZA (azacitidine) MDS

13.12.2007

http://www.bionity.com/news/d/75708/?WT.mc_id=ca0067
Neuartiger Antikörper zur Behandlung von akuter myeloischer Leukämie (AML) vielversprechend in präklinischen Studien
7G3, Leukämiestammzelle (LSC)

11.6.2007

http://idw-online.de/pages/de/news211679
Akute Leukämie: Nutzen bestimmter Formen der Stammzelltransplantation ist derzeit nicht belegt
Leukämie, A-L-L, AML

29.8.2011

http://www.eurekalert.org/pub_releases/2011-08/uhn-nrv082611.php
New research validates clinical importance of leukemia stem cells
personalized treatment, acute myeloid leukemia (AML), leukemia stem cells (LSC), Kolja Eppert, Eric Lechman and Katsuto Takenaka, Peter van Galen, John Dick, AML-biomarkers, stem-cell-signature

13.7.2007

http://www.eurekalert.org/pub_releases/2007-07/osu-gap070907.php
Gene's activity points to more lethal subtype of AML
acute myeloid leukemia ERG

28.2.2005

http://www.eurekalert.org/pub_releases/2005-02/uorm-pda022205.php
Plant derivative attacks the roots of leukemia
Leukämie bekämpfen, Gänseblümchen Daisy, COX-2-Hemmer Parthenolid, Feverfew, AML, CML

1.8.2011

http://www.eurekalert.org/pub_releases/2011-07/cshl-csr072911.php
CSHL scientists reveal mechanism behind 'oncogene addiction' in acute leukemia
acute myelogenous leukemia (AML), MLL-AF9

12.8.2005

http://www.jci.org/cgi/content/full/115/8/1963#SEC1
Learning how leukemia comes to life
Ursache Leukämie, AML, AML1-ETO, FLT3 length mutation, G-CSF

5.11.2009

http://www.eurekalert.org/pub_releases/2009-11/fhcr-fuo110509.php
First use of antibody and stem cell transplantation to successfully treat advanced leukemia
CD45 antigen receptor, myelodysplastic syndrome, AML

14.8.2006

http://www.eurekalert.org/pub_releases/2006-07/hhmi-nsr071406.php
New strategy rapidly identifies cancer targets
kinase, acute myeloid leukemia, AML, RNA, JAK3 Gen

18.3.2007

http://www.uni-protokolle.de/nachrichten/id/127630/
Böser Zwilling eines Hoffnungsträgers - Krebsstammzellen als möglicher Angriffspunkt bei Leukämie
Krebsstammzelle, Privatdozent Dr. Christian Buske, Krebstherapie, CALM-AF10-Fusionsgen, AML, mouse model, B220

3.12.2011

http://jco.ascopubs.org/content/29/34/4592.short?rss=1
DNMT3A Mutations in Acute Myeloid Leukemia: Impact on Low-Risk Patients With CEBPA Mutations
Leukemia, Low-Risk, AML

3.12.2011

http://www.aerzteblatt.de/v4/news/news.asp?id=45258
Deutsches Ärzteblatt: Nachrichten "Wie Gene die Leukämie starten"
AML, Proliferation der Knochenmarkzellen, Insertional mutagenesis, Npm1, Nucleophosmin

3.12.2011

http://www.eurekalert.org/pub_releases/2011-07/cshl-csr072911.php
CSHL scientists reveal mechanism behind 'oncogene addiction' in acute leukemia
AML, oncogene-addiction, Fusion oncoprotein MLL-AF9, Myb, aberrant-self-renewal

23.11.2008

http://www.aerzteblatt.de/v4/news/news.asp?id=34295
Medizin: Leukämie-Genom sequenziert: Zehn Mutationen erklären AML
Leukämie Genom, Jürg Schwaller

3.12.2011

http://idw-online.de/pages/de/news328956
Neuer Behandlungsansatz bei Leukämie
AML Antikörper, Angel Lopez

21.12.2007

http://idw-online.de/pages/de/news240276
Die Rolle von MicroRNAs in der Stammzellentwicklung und bei Leukämie
PU.1 Dysregulation, miRNA 155, Hodgkin-Lymphom, MIRNA-155, Gerhard Behre AML

10.7.2009

http://idw-online.de/pages/de/news325480
Hilfe gegen Leukämie
AML, Andreas Burchert, Andreas Neubauer, Sorafenib, FLT3-ITD-Gen, Stammzelltransplantation

4.10.2009

http://idw-online.de/pages/de/news325480
Hilfe gegen Leukämie
Leberkrebs, AML, FLT3-ITD, Andreas Burchert, AML-Therapie, Sorafenib

3.12.2011

http://www.nature.com/nature/journal/v478/n7370/full/nature10334.html
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
AML

3.12.2011

http://www.sciencecodex.com/researchers_discover_key_mutation_in_acute_myeloid_leukemia
Researchers discover key mutation in acute myeloid leukemia
AML, DNMT3A mutation

22.3.2007

http://www.eurekalert.org/pub_releases/2006-10/uotm-tmt100306.php
Three molecular triggers threaten leukemia patients
acute myelogenous leukemia (AML) PKCa, RAS/Raf/MEK/ERK and PI3/AKT, AML activation

3.12.2010

http://www.eurekalert.org/pub_releases/2010-12/nyph-nci120310.php
New clue in leukemia mystery: Researchers identify 'poison' employed by deadly enzyme mutations
acute myelogenous leukemia (AML) IDH1 IDH1, TET2

2.12.2011

http://jco.ascopubs.org/content/29/34/4592.short?rss=1
DNMT3A Mutations in Acute Myeloid Leukemia: Impact on Low-Risk Patients With CEBPA Mutations
Acute-Myeloid-Leukemia DNMT3A-Mutation

14.6.2008

http://www.eurekalert.org/pub_releases/2008-06/cchm-mam060308.php
Microenvironment a main driver of aggressive multi-lineage leukemia disease type
MLL-AF9 fusion, AML A-L-L, Rac1, MLL, CLL

4.9.2011

http://www.eurekalert.org/pub_releases/2011-09/uow-gdt090211.php
Gene defect that predisposes people to leukemia discovered
acute myeloid leukemia and myelodysplasia, GATA2 mutations, RUNX1 and CEBPA mutations

14.7.2010

http://www.eurekalert.org/pub_releases/2010-07/wifb-ptp070710.php
Protein that predicts prognosis of leukemia patients may also be a therapeutic target
Musashi-2 Musashi 2 CML, AML

14.6.2008

http://www.sciencedaily.com/releases/2008/06/080609124602.htm
Microenvironment A Main Driver Of Aggressive Multi-lineage Leukemia Disease Type
MLL, microenvironment of blood-forming tissues, AML, CLL, A-L-L, CLL, MLL-AF9-fusion

3.12.2011

http://www.sciencedaily.com/releases/2010/01/100112165246.htm
Drug that modifies gene activity could help some older leukemia patients
AML, decitabine, excess methylation

26.3.2010

http://www.eurekalert.org/pub_releases/2010-03/chb-tcp032510.php
Targeting cell pathway may prevent relapse of leukemia
cell-pathway relapse-of-leukemia Indomethacin beta-catenin, AML, Hoxa9, Meis1

14.4.2010

http://www.physorg.com/news190395813.html
“Vicious Circle” Offers New Acute Leukemia Treatment Target
Vicious-Circle, KIT-protein, tyrosine kinase inhibitors, miR-29b, AML

3.12.2011

http://www.sciencedaily.com/releases/2010/12/101203113237.htm
New clue in leukemia mystery: Researchers identify 'poison' employed by deadly enzyme mutations
AML IDH1 IDH2 TET2 methylation

17.2.2009

http://derstandard.at/?id=1234370657645
Kontrolle des HI-Virus durch Stammzellen
akute myeloische Leukämie, HIV-resistent Knochenmark, CD4-Rezeptor, CXCR4, CCR5-Co-Rezeptor

2.1.2009

http://www.uphs.upenn.edu/news/News_Releases/nov06/leukemiatrib.htm
"Tribbles" Implicated in Common and Aggressive Form of Leukemia
AML

13.1.2010

http://www.eurekalert.org/pub_releases/2010-01/wuso-dtm011210.php
Drug that modifies gene activity could help some older leukemia patients
decitabine, AML

2.6.2011

http://www.eurekalert.org/pub_releases/2011-06/kcl-sct060111.php
Stem cell treatment to prevent leukemia returning is a step closer, say scientists
AML, MLL, Hoxa9, Bmi1

3.12.2011

http://www.newswise.com/articles/view/570542/
Mutations in Single Gene Predict Poor Outcomes in Adult Leukemia
DNMT3A AML

31.1.2008

http://www.newswise.com/articles/view/537240/
Leukemia Relapse Stems from DNA Repair Function Loss
DNA mismatch repair (MMR), AML

22.6.2008

http://www.biologynews.net/archives/2008/06/17/gene_mutation_improves_leukemia_drugs_effect.html
Gene mutation improves leukemia drug's effect
RAS mutations AML cytarabine

8.1.2010

http://www.eurekalert.org/pub_releases/2010-01/nyph-rdg010710.php
Researchers discover genetic differences between lethal and treatable forms of leukemia
AML, DNA-methylation

8.2.2008

http://www.news-medical.net/?id=34788
Leukemia relapse stems from DNA repair function loss
AML, minimal residual disease (MRD)

3.12.2011

http://www.sciencedaily.com/releases/2009/10/091005123034.htm
New Target For Treating Leukemia Identified
AML, EGFR, Spleen tyrosine kinase (Syk), Syk-inhibitor

4.8.2011

http://medicalxpress.com/news/2011-08-unconventional-cancer-powerful-drug-candidate.html
Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia
AML, RNAi screen, Brd4

2.7.2009

http://www.eurekalert.org/pub_releases/2009-07/cp-ntt062409.php
New targeted therapy finds and eliminates deadly leukemia stem cells
CD123 LSCs interleukin-3 receptor AML

3.12.2011

http://www.aerzteblatt.de/v4/news/news.asp?id=40200
Deutsches Ärzteblatt: Nachrichten "Forscher finden eine genetische Ursache für Leukämien"
AML, Isocitrat-Dehydrogenase 1 und 2 (IDH), Craig Thompson, IDH1 IDH2

25.3.2010

http://www.eurekalert.org/pub_releases/2010-03/uom-ngt032510.php
New gateway to treat leukemia and other cancers
SLC22A16, AML, Bleomycin

30.11.2006

http://www.uphs.upenn.edu/news/News_Releases/nov06/leukemiatrib.htm
“Tribbles” Protein Implicated in Common and Aggressive Form of Leukemia
AML, Tribbles-2 (Trib-2), C/EBP-alpha

26.11.2006

http://www.eurekalert.org/pub_releases/2006-11/uotm-tls111706.php
Targeting leukemic stem cells by Bcl-2 inhibition
AML cells Apoptosis

2.1.2009

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003909
Acute Myeloid Leukemia-Targeted Toxin Activates Both Apoptotic and Necroptotic Death Mechanisms
Acute Myeloid Leukemia, diphtheria toxin GM-CSF (DT-GMCSF)

11.4.2008

http://www.eurekalert.org/pub_releases/2008-04/embl-auw040308.php
An unexpected way to cause leukemia
C/EBPa, AML

11.4.2008

http://www.biologynews.net/archives/2008/04/08/an_unexpected_way_to_cause_leukemia.html
An unexpected way to cause leukemia
C/EBPa AML

29.11.2007

http://www.sciencedaily.com/releases/2007/11/071128101317.htm
Key Genetic Trigger Of Acute Myeloid Leukemia Identified
N-Myc

22.12.2010

http://www.eurekalert.org/pub_releases/2010-12/jaaj-aoc121610.php
Activity of certain stem cell genes linked with worse outcomes in acute myeloid leukemia patients
leukemic stem cells (LSC)

29.11.2007

http://www.news-medical.net/?id=32965
Discovery of key acute myeloid leukemia gene
N-Myc

12.9.2011

http://www.eurekalert.org/pub_releases/2011-09/iuso-cdm090811.php
Cardiovascular drug may offer new treatment for some difficult types of leukemia
Rho kinase, or ROCK, KIT, FLT3, BCR-ABL, ROCK inhibitor, Fasudil, acute myelogenous leukemia

3.12.2011

http://www.nih.gov/news/health/nov2010/nhgri-10.htm
Researchers discover key mutation in acute myeloid leukemia
DNMT3A

3.12.2011

http://www.sciencedaily.com/releases/2010/06/100603172217.htm
Oncologists fight leukemia with two-pronged therapy, clinical trials planned
AML, Oxi4503, VEGF-A, Leukämie-Medikament

23.7.2009

http://www.eurekalert.org/pub_releases/2009-07/sumc-lc072009.php
Leukemia cells evade immune system by mimicking normal cells, Stanford studies show
CD47, acute myeloid leukemia

31.1.2008

http://www.newswise.com/articles/view/537211/?sc=rsla
Kidney Cancer Drug Attacks a Major Type of Acute Myeloid Leukemia
sorafenib

28.3.2011

http://www.eurekalert.org/pub_releases/2011-03/wtsi-tgp032411.php
The gene processes that drive acute myeloid leukaemia
NPM1

7.7.2009

http://www.eurekalert.org/pub_releases/2009-07/uhn-trd070309.php
Toronto researcher's discovery points to a new treatment avenue for acute myeloid leukemia
CD123 antibody

3.12.2011

http://medicalxpress.com/news/2011-08-stem-cell-mobilization-therapy-safe.html
Stem cell mobilization therapy found to be safe for bone marrow donors
AML, G-CSF, MDS, peripheral blood stem cells, PBSCs, PBSC donors

13.12.2007

http://www.eurekalert.org/pub_releases/2007-12/ohs-oci120507.php
OHSU Cancer Institute researcher develops test for targeted therapy in acute myeloid leukemia
RNAi

15.8.2008

http://content.nejm.org/cgi/content/short/359/6/653?rss=1&query=current
CORRESPONDENCE: MicroRNA in Acute Myeloid Leukemia
microRNA-181

3.12.2011

http://www.bionity.com/de/news/133527/mhh-wissenschaftler-finden-blutkrebs-ausloeser.html
MHH-Wissenschaftler finden Blutkrebs-Auslöser - - Genetischer Schalter erforscht, der aggressiven Blutkrebs zulässt
MN1, Blutkrebs-Auslöser MEIS1 AML

19.1.2008

http://www.innovations-report.de/html/berichte/medizin_gesundheit/bericht-101469.html
Molecules might identify high-risk acute-leukemia patients
Biomarker AML

24.11.2006

http://www.uphs.upenn.edu/news/News_Releases/nov06/leukemiatrib.htm
“Tribbles” Protein Implicated in Common and Aggressive Form of Leukemia
Protein Tribbles AML

15.1.2011

http://derstandard.at/1293370448070/Differenzierung-Blutstammzellen-legen-sich-schon-frueh-fest
Blutstammzellen legen sich schon früh fest
AML C/EBPa

10.3.2008

http://www.biologynews.net/archives/2008/03/07/low_microrna_level_linked_to_high_gene_activity_in_aml.html
Low micro-RNA level linked to high gene activity in AML
NPM1 miR-204 FLT3 miR-155

10.3.2008

http://www.eurekalert.org/pub_releases/2008-03/osum-lml030608.php
Low micro-RNA level linked to high gene activity in AML
NPM1 miR-204 FLT3 miR-155

12.3.2008

http://www.innovations-report.de/html/berichte/studien/bericht-105295.html
Low micro-RNA level linked to high gene activity in AML
NPM1 miR-204 FLT3 miR-155

16.5.2011

http://www.eurekalert.org/pub_releases/2011-05/wfbm-srn051311.php
Study reveals need for personalized approach in treatment of AML
FLT3 receptor, internal tandem duplication (ITD)

13.7.2007

http://idw-online.de/pages/de/news218436
Forschungsergebnisse des Universitätsklinikums Ulm öffnen neue Wege zur Überwindung von Chemotherapie-Resistenzen bei Leukämie-Patienten
Chemotherapieresistenz AML, Core Binding Factor (CBF) Leukämie

3.12.2011

http://www.medindia.net/news/Hunt-For-New-Cancer-Targets-Leads-To-A-Powerful-Drug-Candidate-For-AML-88713-1.htm
Hunt For New Cancer Targets Leads To A Powerful Drug Candidate For AML
AML Brd4 RNAi

5.12.2007

http://www.jci.org/cgi/content/short/117/12/3696?rss=1
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice
AML

4.11.2009

http://www.eurekalert.org/pub_releases/2009-11/uog-tgc110309.php
2 genes cooperate to cause aggressive leukemia
RAS, NF1, K-RAS, Mutation, AML

3.12.2011

http://www.eurekalert.org/pub_releases/2010-05/sjcr-suo050710.php
Smarter use of existing treatment helps dramatically boost survival of young AML patients
minimal residual disease (MRD), gemtuzumab ozogamicin, cytarabine

13.12.2009

http://www.eurekalert.org/pub_releases/2009-12/dci-ctw120409.php
Combination therapy with midostaurin improves survival of AML patients with FLT3 mutations, phase 1

8.6.2008

http://www.newswise.com/articles/view/541359/?sc=rsla
Data Show Encouraging Results for a Potential New Front-Line Treatment Approach in AML
anthracycline clofarabine

12.8.2007

http://www.eurekalert.org/pub_releases/2007-08/osu-atb080107.php
Aggressive therapy best for certain AML patients

3.12.2011

http://www.medindia.net/news/New-Cancer-causing-Mechanism-Identified-77621-1.htm
New Cancer-causing Mechanism Identified
AML, IDH1 IDH2 TET2